ZFIN Image: De Smet et al., 2014, Fig. 4

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Figure Caption

Fig. 4

Role of FGFs in Other Angiogenesis Processes in Zebrafish

(A and B) Fluorescent images (ventral view) of GFP⁺ subintestinal vessels (SIVs) on the surface of the yolk sac of 72 hpf Tg(fli1:EGFP)^y1 zebrafish embryos, revealing normal SIVs after exposure to DMSO (A) and severe underdevelopment of these SIVs after exposure to 50 μM SSR (tissue concentration 1.9 μg SSR/mg protein) from 20 hpf onward (arrowheads in B).

(C and D) Images (lateral view) of the GFP⁺ vascular plexus (VP) in the posterior trunk of 45 hpf Tg(fli1:EGFP)^y1 zebrafish embryos. In DMSO treated control embryos (C), a vascular plexus formed via branching from the caudal vein. After exposure to 200 μM SSR (tissue concentration 3.9 μg SSR/mg protein) from 20 hpfs onward, the vascular plexus failed to remodel and branch and, instead, only a large vascular syncytium was formed (D). In all panels, the head of the embryo faces left; scale bars denote 50 μm in (A) and (B) and 100 μm in (C) and (D).

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Acknowledgments

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