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Fig. S1
KRASG12D overexpression in zebrafish cerebellum induces medulloblastoma (MDB). A-D: Appearance of EGL (A) and 4th VZ (B) in normal cerebellum; zebrafish injected with KRASG12D develop early cerebellar lesions (C,D), which resemble medulloblastoma, starting from 15 dpf. E, F: Analysis of the histological features in 1 mpf zebrafish cerebellum reveals tumour masses (E) that resemble the classic type of human medulloblastoma (F) with sheets of small round blue cells with scant cytoplasm. (G) Schematic representation of a normal cerebellum, with EGL and VZ locations.
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