ZFIN Image: Zhu et al., 2014, Fig. 6

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Figure Caption

Fig. 6

Constitutive activation of TGFβ signalling promotes ColI deposition at the amputation site in def^+/- fish after PH.

(A–D) Representative images of immunostaining of pSmad2 (red) and Bhmt (green) in wound epidermis in wild-type (A), def^+/- (B), def^+/- treated with SB431542 (C) or def^+/-treated with Dex (D) 1.5, 3 and 5 days after PH, respectively. (E,F) Representative images of immunostaining of ColI (red) and Bhmt (green) in the wound epidermis in wild-type and def^+/-fish treated or not treated with SB431542 (E) or Dex (F) 5 days after PH, respectively. Nuclei were stained with DAPI (blue). In each case, more than 10 sections from at least three wild-type or def^+/- mutant fish were examined. bc, blood clot; lv, liver tissue; we, wound epidermis. Scale bar:75 μm (A–F).

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Acknowledgments

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