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Fig. 3
Mislocalization of mutant FUS-GFP was also found in motor neurons.
(A) FUS-R521C-GFP was similarly mislocalized to the cytosol in motor neurons (labeled with 39.4D5 for islet1 and islet2 homeodomain marker). (B) Quantification of FUS-GFP signal in nucleus vs. cytosol in 39.4D5 marked motor neurons demonstrated that FUS-R521C-GFP was significantly more cytosolic compared to FUS-WT-GFP (post-hoc Tukey HSD. ** = P<0.01, N.S. = >0.05, n = 40 for all samples. Error bars represent SE. Scale bars = 20 μm.
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