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Fig. S4 Injecting high doserhouaRNA results in enlarged and dysmorphic hearts. (A, B, E, F) Similar to (A, E) control Tg(cmlc2:ras-eGFP) embryos (n = 79), (B, F) injection of 150 pg of rhoua RNA into wild-type Tg(cmlc2:ras-eGFP) embryos did not cause any significant cardiac phenotypes (n = 0/33). However, (C, G) injection of 300 pg of rhoua resulted in larger and dysmorphic hearts (n = 55/77), which is in contrast to the smaller hearts observed in (D, H) rhoua MO injected embryos (n = 83/102). Arrow points to pericardial edema.
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Reprinted from Developmental Biology, 389, Dickover, M., Hegarty, J.M., Ly, K., Lopez, D., Yang, H., Zhang, R., Tedeschi, N., Hsiai, T.K., Chi, N.C., The atypical Rho GTPase, RhoU, regulates cell-adhesion molecules during cardiac morphogenesis, 182-91, Copyright (2014) with permission from Elsevier. Full text @ Dev. Biol.