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Fig. S7
Morphological assessment of zebrafish embryos injected with 100 pg of sfrp5 mRNA. One-cell stage embryos were injected with a high dose (100 pg) of sfrp5 mRNA. Embryos were grown to 22 hpf and analyzed for gross morphological defects. Uninjected controls display no aberrations in either eye or alterations to axis specification (A-B, n=63/63). Of the embryos injected with a high dose of sfrp5 mRNA, 5/51 display no overt phenotype (C-D), 31/51 display subtly elongated eyes and very mild dorsalization (E-F), and 10/51 display extensive elongation of eyes as well as moderate dorsalization (G-H).
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Reprinted from Developmental Biology, 388(2), Holly, V.L., Widen, S.A., Famulski, J.K., and Waskiewicz, A.J., Sfrp1a and Sfrp5 function as positive regulators of Wnt and BMP signaling during early retinal development, 192-204, Copyright (2014) with permission from Elsevier. Full text @ Dev. Biol.