ZFIN Image: Essers et al., 2014, Fig. 6

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Figure Caption

Fig. 6

Loss of p53 partially rescues mutant phenotypes. (A) Bright field microscopy of p53 MO injections at 2 dpf. UIC=uninjected control embryos. Arrows depict inflation of the hindbrain ventricle, arrowheads depict enlargement of the forebrain. The ragged skin phenotype in gnl3l mutants and the rescue are depicted with the black bars. (B) Representative profiles of mutant embryos injected with the p53 MO. (C) Magnified representation of polysome profiles showing an increase in 60S peak size in p53 MO compared to missense MO injected embryos. (D) Quantification of the ratio of 60S to 40S peak size in missense vs. p53 MO injected embryos.

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Phenotype details

Acknowledgments

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Reprinted from Developmental Biology, 385(2), Essers, P.B., Pereboom, T.C., Goos, Y.J., Paridaen, J.T., and Macinnes, A.W., A comparative study of nucleostemin family members in zebrafish reveals specific roles in ribosome biogenesis, 304-15, Copyright (2014) with permission from Elsevier. Full text @ Dev. Biol.