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Figure Caption
Fig. S9 p53 inhibition rescues high levels of phospho-histone H3 staining in ESCO2 morphants. (A). Embryos (1–2 cells) were co-injected with ESCO2-5mis or ESCO2-Splice MO (10 ng), and a control morpholino (Control-MO) from Gene Tools or p53 morpholino (p53-MO). At 24 h.p.f., the embryos were dechorionated and immunostained with anti-phospho-Histone H3 antibody to detect mitotic cells in G2/M stage. (B). The number of phospho-histone H3 positive cells was quantified for 5 embryos per group. P<0.0001, ESCO2-5mis+Control-MO vs ESCO2-MO+Control-MO; P<0.0001, ESCO2-MO+Control-MO vs ESCO2-MO+p53-MO.
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