ZFIN Image: Sheehan-Rooney et al., 2013, Fig. 2

Image

Figure Caption

Fig. 2

Inhibition of Hsp90 partially restores trabeculae in severe mutants. (A) Zebrafish embryos were treated with levels of 17AAG that did not disrupt the craniofacial skeleton in wild type. (B) Untreated gata3 mutants in the severe background typically lack trabeculae (arrowheads). (C) Hsp90 inhibition partially restored the trabeculae, resulting in the fusion of the palate and posterior neurocranium. (D) 17AAG treatment of severe gata3 mutants significantly increases the number of trabeculae in treated embryos (average=0.95, s.e.m.=0.211, s.d.=0.94, n=20) compared with control, DMSO-treated, embryos (average=0.13, s.e.m.=0.05, s.d.=0.34, n=39). (A–C) Dorsal views of flat-mounted neurocrania, anterior to the left; ep, ethmoid plate; tr, trabeculae.

Figure Data

Phenotype details

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Dis. Model. Mech.