ZFIN Image: Abramsson et al., 2013, Fig. 6

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Figure Caption

Fig. 6 Impaired patterning of the secondary motor neurons. The Tg(isl1:GFP ) is expressed in SMNs of controls (A) but is reduced in appbMO injected embryos (B). Staining with the SMN-specific antibody zn5 shows irregular projections and stalled outgrowth of the SMN in appb morpholino injected embryos (B) compared to controls (A). The Tg(gata2:GFP) transgene shows that the irregular patterning of extending axons persist in morphants (D) while controls (C) have a regular pattern of SMN by 3 dpf. The dorsolateral fasciculus (DLF) which extends to the end of the spinal cord in controls (E) is projecting out to the tip of the tail fin in appb morphants (arrow, F). The contour of the tail fin is outlined by a dotted line. Bar: 20 μm.

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Acknowledgments

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Reprinted from Developmental Biology, 381(2), Abramsson, A., Kettunen, P., Banote, R.K., Lott, E., Li, M., Arner, A., and Zetterberg, H., The zebrafish amyloid precursor protein-b is required for motor neuron guidance and synapse formation, 377-88, Copyright (2013) with permission from Elsevier. Full text @ Dev. Biol.