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Fig. 5 Defective primary motor neurons. PMNs in the spinal cord of control embryos (A), trslMO (B) and trslMO +mRNA (C) injected Tg(mnx1:GFP) embryos (B) have dorsally projecting MiPs (arrow) and ventrally projecting CaP (arrowhead). Staining of control (D), trslMO (E) and trslMO +mRNA (F) injected embryos using znp1. CaP neurons stalling was observed in trslMO injected embryos (N). Measurement of the length of CaP (G) and MiP (H). Bar is 20 μm. Two-way ANOVA test: NNNP<0.0005, NP<0.05, n.s.=not significant.
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Reprinted from Developmental Biology, 381(2), Abramsson, A., Kettunen, P., Banote, R.K., Lott, E., Li, M., Arner, A., and Zetterberg, H., The zebrafish amyloid precursor protein-b is required for motor neuron guidance and synapse formation, 377-88, Copyright (2013) with permission from Elsevier. Full text @ Dev. Biol.