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Fig. 4 Expression of appb at 11, 24 and 48 hpf. The expression of appb is prominent in axial structures at 11 hpf (A) and is expressed in telencephalon, spinal cord neurons and pronephric duct and dorsal aorta by 24 hpf (B,C). Cross section at the caudal hindbrain and spinal cord shows expression in developing motor neurons and interneurons (D,E). The expression of appb becomes restricted to CNS at 48 hpf, (F). Scale bars: A, 100 μm; C, 80 μm; D, 40 μm.
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Reprinted from Developmental Biology, 381(2), Abramsson, A., Kettunen, P., Banote, R.K., Lott, E., Li, M., Arner, A., and Zetterberg, H., The zebrafish amyloid precursor protein-b is required for motor neuron guidance and synapse formation, 377-88, Copyright (2013) with permission from Elsevier. Full text @ Dev. Biol.