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Fig. 7 Abnormal development of cardiac NCCs contributes to heart defects in the eif3ba mutant shown by Tg(flk:EGFP) fish line. (A)–(D′) The bulbus arteriosus (OFT, arrow) normally forms at <2 dpf in the wild-type, while in the mutant at the same stage, the OFT remains in the shape of a long tube. (B, B′, D, D′) Higher magnification images of the OFT in wild-type and mutant embryos. (A)–(D) Fluorescence images captured under the confocal microscope. (A′)–(D′) Bright field images merged with the corresponding fluorescence images from (A)–(D). WT, wild type; Mut, eif3ba mutant.
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Reprinted from Developmental Biology, 381(1), Xia, Z., Tong, X., Liang, F., Zhang, Y., Kuok, C., Zhang, Y., Liu, X., Zhu, Z., Lin, S., and Zhang, B., Eif3ba regulates cranial neural crest development by modulating p53 in zebrafish, 83-96, Copyright (2013) with permission from Elsevier. Full text @ Dev. Biol.