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Fig. 5 ztfpi-2 regulated the development of the midbrain and hindbrain. All views are lateral. Expression of pax2a in the MHB (A) egr2b in rhombomere 5 (B) at 25 hpf. Embryos injected with 0.5 mM SP-MO displayed weaker expression of pax2a (arrow) and egr2b (asterisk) than those exposed to 0.5 mM Mcon-MO, while wild-type ztfpi-2 RNA was able to rescue their expression in the same region. Also, her4 and mib were able to partially rescue the ztfpi-2 defects in the midbrain and hindbrain. Scale bar: 50 μm.
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Reprinted from Developmental Biology, 381(1), Zhang, Y., Wang, L., Zhou, W., Wang, H., Zhang, J., Deng, S., Li, W., Li, H., Mao, Z., and Ma, D., Tissue factor pathway inhibitor-2: A novel gene involved in zebrafish central nervous system development, 38-49, Copyright (2013) with permission from Elsevier. Full text @ Dev. Biol.