|
Fig. 3
Inhibition of AADC by NSD-1015 in zebrafish.
AADC inhibitor NSD-1015 caused morphological and behavioral defects. Compared to untreated fish, the inhibited larvae became shorter by gradient increase of NSD-1015 concentration. (A) The phenotype of treated larvae. From up to bottom is the untreated larvae (n=234), and treated larvae by inhibitor NSD-1015 100 μM(n= 312), 200 μM (n=300), 300 μM (n=304), 400 μM (n=264), and 500 μM (n=260). (B–C) The statistics of body length and movement in touch response, respectively, and showed the decrease of body length and movement in touch response in larvae treated with NSD-1015. (D) Sequencing touch response for untreated (upper panel) and treated larvae (bottom panel), showing decreased movement in touch response in larvae treated with NSD-1015. Results were expressed as mean±SD. **p<0.01, ***p<0.001 compared to control larvae.