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Fig. S8 PD98059 and TPCK suppress dusp6 upregulation in Tg(hsp70-HRASG12V) embryos in a dose-dependent manner. dusp6 expression was assessed by ISH. (A,B) Tg(hsp70-HRASG12V) receiving heat shock or no heat shock treatment provided positive and negative controls. (C-E) Tg(hsp70-HRASG12V) receiving PD98059 treatment in an increasing dose demonstrated a decreasing expression level of dusp6. (F-H) Tg(hsp70-HRASG12V) receiving TPCK treatment in an increasing dose demonstrated a decreasing expression level of dusp6.
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