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Fig. 3 Intestinal enterocytes differentiate with characteristic markers in ascl1a-/- 5 dpf embryos. Enterocytes differentiate within the ascl1a-/- intestinal epithelium as demonstrated by apical alkaline phosphatase (blue in (B) compared to WT in (A)), apical sodium phosphate transporter (NaPi) (green in (D) compared to WT in (C)), and the tight junction marker ZO-1 (green in (F) compared to WT in (E)). Apical alkaline phosphatase in ascl1a-/- is typically less than WT but NaPi and ZO-1 are present at the same intensity. Scale bar represents 50 μm except in (A) and (B) where the bar is 20 μm.
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Reprinted from Developmental Biology, 376(2), Roach, G., Heath Wallace, R., Cameron, A., Emrah Ozel, R., Hongay, C.F., Baral, R., Andreescu, S., and Wallace, K.N., Loss of ascl1a prevents secretory cell differentiation within the zebrafish intestinal epithelium resulting in a loss of distal intestinal motility, 171-186, Copyright (2013) with permission from Elsevier. Full text @ Dev. Biol.