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Fig. S7 Warfarin treatment of zebrafish at 24 hpf results in cranial hemorrhaging. (A-D) Micrographs of (A,C) DMSOand (B,D) warfarin-treated Tg(gata1:dsRed);Tg(kdrl:GFP) zebrafish shows that warfarin exposure at 24 hpf can cause cranial hemorrhages by 48 and 72 hpf. (E) 78% of warfarin-treated zebrafish at 24 hpf displayed cranial hemorrhaged by 48 hpf, which increased to 96% by 72 hpf. All reh mutants but no DMSO-treated zebrafish exhibited cranial hemorrhage at 48 and 72 hpf.
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