ZFIN Image: Garnaas et al., 2012, Fig. s2

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Figure Caption

Fig. s2 The pan-RAR antagonist AGN193109 reduces liver size and hepatic proliferation. (A-B) Embryos treated with the RAR antagonist AGN193109 from 18-24 hpf develop smaller livers compared to DMSO-treated controls as shown by lfabp expression at 72 hpf. Lateral views. (C) Quantification of the number of proliferating BrdU+ cells in the area of the liver primordium (see Figure 1, black rectangle) in AGN193109-treated embryos at 24 hpf. (D) FACS quantification of percent GFP+ cells in chemically treated lfabp:GFP embryos reveals that AGN193109-treated embryos contain fewer hepatocytes than DMSO-treated controls.

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Reprinted from Developmental Biology, 372(2), Garnaas, M.K., Cutting, C.C., Meyers, A., Kelsey, P.B., Harris, J.M., North, T.E., and Goessling, W., Rargb regulates organ laterality in a zebrafish model of right atrial isomerism, 178-189, Copyright (2012) with permission from Elsevier. Full text @ Dev. Biol.