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Fig. 4 Knockdown of Notch1a rescues retinoblast proliferation defects in Id2a-deficient retinae. (A)–(D) pH3 immunohistochemistry was used to quantify retinoblasts in late G2/M in transverse retinal sections from (A) Id2aMM, (B) Id2aMO, (C) N1aMO and (D) Id2aMO/N1aMO embryos at 48 hpf. Average total cell number per retinal section was determined for each condition (E), as well as the average percentage of pH3-positive cells per retinal section (F). Dorsal is up in all images. Error bars represent SEM, n=9; *p<0.05, ** p<0.005.
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Reprinted from Developmental Biology, 371(2), Uribe, R.A., Kwon, T., Marcotte, E.M., and Gross, J.M., Id2a functions to limit Notch pathway activity and thereby influence the transition from proliferation to differentiation of retinoblasts during zebrafish retinogenesis, 280-292, Copyright (2012) with permission from Elsevier. Full text @ Dev. Biol.