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Fig. 7
Shh signaling defects in hmx4 morphants are rescued by RA. 18 hpf hmx4 morphants show a reduction of ptc1 (A–D) and nkx2.2a (E–H) that are significantly rescued by RA treatment (see text for frequencies and statistical tests). Black lines indicate the size of gene expression domains on the dorsal–ventral axis, for comparison of control hmx4 morphants and RA-treated hmx4 morphants.
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Reprinted from Developmental Biology, 355(1), Gongal, P.A., March, L.D., Holly, V.L., Pillay, L.M., Berry-Wynne, K.M., Kagechika, H., and Waskiewicz, A.J., Hmx4 regulates Sonic hedgehog signaling through control of retinoic acid synthesis during forebrain patterning, 55-64, Copyright (2011) with permission from Elsevier. Full text @ Dev. Biol.