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Fig. S4
Effect of neucrin on the expression of targeted genes of Wnt/β-catenin signaling. (A–D) The expression of sp5l in wild-type (A), wnt8a RNA-injected (B), neucrin RNA-injected (C), and wnt8a RNA- and neucrin RNA-injected (D) embryos at 8 hpf. Dorsal view with anterior to the top. (E and F) The expression of otx2 in wild-type (E) and neucrin RNA-injected (F) embryos at 8 hpf. Lateral view with anterior to the left. Scale bar: 100 μm.
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Reprinted from Mechanisms of Development, 128(11-12), Miyake, A., Nihno, S., Murakoshi, Y., Satsuka, A., Nakayama, Y., and Itoh, N., Neucrin, a novel secreted antagonist of canonical Wnt signaling, plays roles in developing neural tissues in zebrafish, 577-590, Copyright (2012) with permission from Elsevier. Full text @ Mech. Dev.