ZFIN Image: Wiweger et al., 2012, Fig. 7

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Figure Caption

Fig. 7

Dental defects are present in 20% of adult ext2^+/- mutant fish.

Lateral view of two ventral teeth stained with Alizarin red. In most cases, WT-like teeth were present (A, D). However, on few occasions we also observed: enamel malformation (B, E, F) or misshapen crowns (C, C2). Teeth start to calcify from the tip toward the base; hence the lack of staining at the base of 2V is most likely reflects uncompleted ossification of a recent replaced tooth – see black arrowhead (C). Teeth from MO patients (G, H). Note extra buckle in H (arrow head) which resembles split crown observed in ext2^-/- fish. C2 is a higher magnification of C. White arrows indicate lesions. Scale bars correspond to 0.1 mm.

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Acknowledgments

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