Fig. 6
Feedback measured in cones is reduced in the mutant zebrafish
(A) Light-induced feedback responses in wild-type (left) and mutant (right) zebrafish cones. Horizontal cells were hyperpolarized by full-field 1 s flashes of light while the recorded cone was saturated with a 20 µm spot of bright light. (B) IV relation of a cone ICa in control (green), 50 µM DNQX (red), and 30 µM KA (black) in wild-type (Bi, left) and mutant (Bii, left). Averaged DNQX- (red) and KA- (black) induced currents in wild-type (Bi, right) and mutants (Bii, right). The DNQX-induced current is significantly reduced in the mutant compared to the current in wild-type.