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Fig. S11
Apoptotic NCCs appear in the arches of vgll2a morphants but not in uninjected embryos at 24 hpf. Single-plane, confocal images showing the pharyngeal arches of a representative uninjected sox10:egfp embryo (A) and a sox10:egfp embryo injected with 5 ng vgll2a MO and 2 ng p53 MO (B) and stained with an anti-active caspase 3 antibody in lateral views. Apoptotic, anti-active caspase 3-postitive NCCs (arrow), were only observed in the arches of vgll2a morphants at 24 hpf. Arches are numbered 1–4. Anterior is to the left in both panels.
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Reprinted from Developmental Biology, 357(1), Johnson, C.W., Hernandez-Lagunas, L., Feng, W., Melvin, V.S., Williams, T., and Artinger, K.B., Vgll2a is required for neural crest cell survival during zebrafish craniofacial development, 269-81, Copyright (2011) with permission from Elsevier. Full text @ Dev. Biol.