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Fig. 8
A model for the roles of BMP and non-canonical Wnt signaling in regulating tail development. Depiction of the tailbud of a 10-somite wild-type zebrafish embryo. During tailbud protrusion, BMP signaling in the posterior tailbud plays a crucial role in guiding the ventroposterior mesoderm cells to move beneath the Kupffer′s vesicle properly. Non-canonical Wnt signaling promotes intercellular adhesion of cells in the caudal end of notochord, allowing them to maintain cohesion during tail elongation. CNH, the caudal end of notochord; nt: notochord; PM, posterior mesoderm; KV, Kupffer′s vesicle.
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