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Fig. S4 Representative pictures at 72 hpf of 5 control transgenic Tg(cd41:EGFP) zebrafish embryos or injected with MOs. The GFP positive cells represent the number of presumed hematopoietic stem cells (cd41low) and thrombocytes (cd41high). For march2 (n=44), max (n=63), smox (n=60), pttg1lp (n=50), emilin1 (n=65) and sufu (n=65), a severe decrease of cd41 positive cells was observed. Ncor2 (n=53) depletion resulted in a mild phenotype, and pdzk1ip1l (n=49) and nfatc1 (n=60) MO injected embryos showed no phenotype.
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Reprinted from Developmental Cell, 20(5), Tijssen, M.R., Cvejic, A., Joshi, A., Hannah, R.L., Ferreira, R., Forrai, A., Bellissimo, D.C., Oram, S.H., Smethurst, P.A., Wilson, N.K., Wang, X., Ottersbach, K., Stemple, D.L., Green, A.R., Ouwehand, W.H., and Göttgens, B., Genome-wide Analysis of Simultaneous GATA1/2, RUNX1, FLI1, and SCL Binding in Megakaryocytes Identifies Hematopoietic Regulators, 597-609, Copyright (2011) with permission from Elsevier. Full text @ Dev. Cell