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Fig. S6 Additional examples of inhibition of Rho kinase, JNK, and cytoskeletal architecture negatively affecting biliary development. (A-F) Whole-mount projections of cytokeratin immunostaining of liver from a 5 dpf control larvae (A), compared to similar stainings from larvae treated with the Rho kinase inhibitors fasudil (B) and H- 1152 (RKI, C), as well as the JNK inhibitor dicoumeral (D), the actin inhibitor cytochalasin D (E), and the microtubule and cytoskeleton inhibitor colchicine (F). gb, gallbladder.
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Reprinted from Developmental Biology, 351(2), Cui, S., Capecci, L.M., and Matthews, R.P., Disruption of planar cell polarity activity leads to developmental biliary defects, 229-241, Copyright (2011) with permission from Elsevier. Full text @ Dev. Biol.