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Fig. S1 Sequence and expression of xA2. (A) Sequence of Xenopus, mouse, and zebrafish APOBEC2, and human APOBEC1. The active site ofAPOBEC1 is boxed. Active center residues, where H100, C130 and C134 coordinate Zn, are labeled with asterisks, and residues mutated in MutXA2 are indicated by red arrowheads. (B, C) xA2 expression is decreased in stage 18 posterior poles (B, 2 and 5 ng Der MO) and stage 12 dorsal halves (C, 5 ng Der MO) of Xenopus embryos depleted of Derriere protein. RT-PCR with ODC as loading control.
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Reprinted from Developmental Biology, 350(1), Vonica, A., Rosa, A., Arduini, B., and Brivanlou, A.H., APOBEC2, a selective inhibitor of TGFβ signaling, regulates left–right axis specification during early embryogenesis, 13-23, Copyright (2011) with permission from Elsevier. Full text @ Dev. Biol.