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Fig. S3 Expression of kita-HRASV12 in mitfa-/- (nacre) background is unable to rescue melanocyte survival. a) Migratory neural crest are the only cells expressing GFP-HRAS in 3 dpf kita-GFP-RAS embryos in a nacre background (b). Compare with fully differentiated, transformed tail melanocytes (c) in a 3 dpf kita-GFP-RAS embryo in a AB background (d). e) 21 dpf nacre x kita-GFP-RAS fish is devoid of melanocytes, as opposed to AB x kita-GFP-RAS fish (f), which has increased pigmentation. Calibration bar 100 mm for a–d; 2 mm for e–f.
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