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Fig. 3 Up-regulation of Wnt signaling causes intestinal hyperplasia. (A) H&E-stained section of an 8-dpf WT (wt) intestinal bulb shows an orderly array of cells in the intestinal epithelium. (B) An 8-dpf axin1 mutant intestine is thicker (bracket) and has more disorganized epithelial cells (*). (C) At both 6 and 8 dpf, axin1 mutants have significantly more BrdU-labeled cells within the intestinal epithelium than wt (P < 0.0001). (D) At 8 dpf, axin1 mutant intestines have significantly more epithelial cells in the bulb and distal intestine vs. wt (P < 0.0001). (Scale bar: A and B, 25 μM.) 4
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