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Figure Caption
Fig. 2 miR-145 overexpression affects gut and heart development. (A–C) Overexpression of miR-145 causes mild pericardial edema (arrowhead) in 24 hpf embryos, (D–F) which then develops into severe pericardial edema accompanied by a unlooped gut at 96 hpf. The control mimic RNA injection has no effect. (G) Overexpression of miR-145 leads to strong down-regulation of sm22α-b but does not affect αsma levels in 48 hpf embryos as measured by qPCR. Arrows, gut. (Scale bar, 200 μm.)
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