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Fig. 5 Pea3 ETS factors are required for heart development. (A–L) In situ hybridization showing cardiac gene expression at 24hpf (A–H) and 48hpf (I–L). Knock-down of multiple Pea3 ETS factors altered amhc (D; red arrowhead indicates midline of embryo) and vmhc expression (H; cell population and spatial arrangement in yellow bracket). Cardiac looping was severely affected in 3EtsMO-injected embryos as shown by expression of cmlc2 (K, L). (M) Quantification of effects on heart looping in MO-injected embryos as exemplified in I; normal looping, K; no looping, L; reverse looping.
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Reprinted from Developmental Biology, 342(1), Znosko, W.A., Yu, S., Thomas, K., Molina, G.A., Li, C., Tsang, W., Dawid, I.B., Moon, A.M., and Tsang, M., Overlapping functions of Pea3 ETS transcription factors in FGF signaling during zebrafish development, 11-25, Copyright (2010) with permission from Elsevier. Full text @ Dev. Biol.