ZFIN Image: Nguyen et al., 2010, Fig. 4

Image

Figure Caption

Fig. 4 Cardiac differentiation phenotypes of leo1^LA1186. Normally, vmhc expression is restricted in the ventricle in wild-type embryos (A), but is expanded into the atrium in leo1^LA1186 mutants (B). Expression of amhc, however, is restricted properly to the atrial chamber in both wild-type (C) and leo1^LA1186 mutant embryos (D). Notch1b transcripts are detected in the endocardium at the AV boundary of wild-type embryos (E), but are absent in leo1^LA1186 mutants (F). Expression of bmp4 (G), versican (I), and wnt2bb (K) are detected in the myocardium of the AV boundary in wild-type embryos. Both bmp4 (H) and versican (J) transcripts are no longer restricted in leo1^LA1186 mutants, while wnt2bb is not detected in mutant embryos (L). Dashed lines (in A–D) and arrows (in E, G, I, K) mark the boundary of atrium and ventricle.

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Expression / Labeling details

Acknowledgments

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Reprinted from Developmental Biology, 341(1), Nguyen, C.T., Langenbacher, A., Hsieh, M., and Chen, J.N., The Paf1 complex component Leo1 is essential for cardiac and neural crest development in zebrafish, 167-175, Copyright (2010) with permission from Elsevier. Full text @ Dev. Biol.