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Fig. 7 Rest knockdown in yot/gli2a mutants represses Hh target gene expression. Lateral view, 30 hpf embryos stained for ptc1 (A–D) or nkx2.2 (E–H) mRNA. rest knockdown in wild-type embryos (B, F) results in modest enhancement of ptc1 and nkx2.2a expression (compare B with A, and F with E). yot/gli2a mutants show characteristic loss of ptc1 (C) and nkx2.2a (G). In yot mutants with compromised Rest function (D, H), the loss of ptc1 (D) and nkx2.2a (H) expression is more pronounced in the midbrain/diencephanlon region (indicated by brackets, D and arrows, H) than in control-injected mutants (C, G).
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Reprinted from Developmental Biology, 340(2), Gates, K.P., Mentzer, L., Karlstrom, R.O., and Sirotkin, H.I., The transcriptional repressor REST/NRSF modulates hedgehog signaling, 293-305, Copyright (2010) with permission from Elsevier. Full text @ Dev. Biol.