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Fig. 3 Inhibition of ChCh and Sip1a affects the components of the "clock and wavefront model." A-I: Flat-mount RNA in situ hybridization of 10-somite stage wild-type, and ChCh and Sip1a compromised embryos. All views are dorsal; anterior to the left. A-F: In wild-type embryos, periodic activation of Notch signaling provides cycling gene expression of Notch pathway genes such as her1 and her7. The number of the her7 expressing stripes in chch and sip1a ATG MO injected embryos ranges from 4 to 5 (B,C; E,F). G-I: fgf8 expression domain at tail bud is expanded anteriorly in ChCh and Sip1a compromised embryos. A-F: Asterisks denote each her1 or her7 expressing premesoderm stripe. G-I: Arrows denote fgf8 tail bud expression domain (G-I).