ZFIN Image: Yue et al., 2009, Fig. S7

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Figure Caption

Fig. S7 β-Arrestin1 Regulates Cdx4-Hox Pathway in Zebrafish
(A-B) Phenotypic analyses of embryos injected with 4 ng β-arrestin1 morpholino or 1 ng cdx4 morpholino at 24 hpf. (C-F) WISH analyses for hoxb5a and hoxb6b expression at 14 hpf. Embryos are dorsal views with anterior to the top. (G) Quantitative real-time PCR verification of the WISH results, and cdx4 mRNA rescue effects at 14 hpf. (H) Quantitative real-time PCR analysis of additional hox genes in zebrafish. Data shown are means ± SEM of at least three independent experiments, *p < 0.05, **p < 0.01, ***p < 0.001 versus the corresponding control. (I-M) Phenotypic analyses of embryos injected with different dosage of hoxa9a morpholino, co-injection with 4 ng p53 morpholino, or injection in a p53 mutant fish background (tp53 M214K). (N-R) Phenotypic analyses of embryos injected with different dosage of hoxb4a morpholino, co-injection with 4 ng p53 morpholino, or injection in a p53 mutant fish background (tp53 M214K).

Acknowledgments

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Reprinted from Cell, 139(3), Yue, R., Kang, J., Zhao, C., Hu, W., Tang, Y., Liu, X., and Pei, G., Beta-arrestin1 regulates zebrafish hematopoiesis through binding to YY1 and relieving polycomb group repression, 535-546, Copyright (2009) with permission from Elsevier. Full text @ Cell