ZFIN Image: Row et al., 2009, Fig. 4

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Figure Caption

Fig. 4 Ectopic Bmp signaling during early somitogenesis alters patterning and morphogenesis. (A, B) Expression of no tail is expanded in the tailbud of transgenic embryos at the 9-somite stage. (C–E) Cell migration, as shown by photoconverted NLS-Kikume fluorescence (red), is disrupted as a result of ectopic Bmp signaling. The graph shows the most anteriorward migration of labeled cells from the posterior end of the embryo in individual embryos. (F, G, H) Cell migration defects are a non-cell-autonomous result of ectopic Bmp signaling. Cell transplants were performed as diagrammed in (F). Cells from a transgenic donor (H) contribute to the same cell types and anterior extent as those from a wild-type donor (G). Embryos were heat shocked at the 3-somite stage.

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Acknowledgments

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Reprinted from Developmental Biology, 329(1), Row, R., and Kimelman, D., Bmp inhibition is necessary for post-gastrulation patterning and morphogenesis of the zebrafish tailbud, 55-63, Copyright (2009) with permission from Elsevier. Full text @ Dev. Biol.