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Fig. 5 Morpholino oligonucleotides do not alter gross development, and specifically inhibit neuroD synthesis. Panels A–C illustrate wt, mismatch control and morphant embryos, respectively, at 72hpf. Note the similarity in body shape and eye size. Panel D is a Western blot of proteins from wt and morphant embryos. Panels E and F illustrate Tg(Hsp70/4:neuroDEGFP) embryos injected with either mismatch (E, F) or atg (G, H) morpholinos, treated with heat shock and 24hpf and photographed at 48hpf. Note the absence of EGFP fluorescence in the morphant embryos (G, H).
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Reprinted from Mechanisms of Development, 126(3-4), Ochocinska, M.J., and Hitchcock, P.F., NeuroD regulates proliferation of photoreceptor progenitors in the retina of the zebrafish, 128-141, Copyright (2009) with permission from Elsevier. Full text @ Mech. Dev.