|
Fig. 9 Side to side comparison of head and body structures visualized by SD-OCT and histology. SD-OCT images (left in each pair) were obtained noninvasively from living embryos, leaving them healthy and capable of continued growth. Similar structural data was obtained histologically, requiring sacrifice and sectioning before any information was obtained, and guaranteeing that any interesting structural observations can never be followed longitudinally. A shows the development of the eyes and ventricle of a 24 hours post fertilization (hpf) embryo. B and C show development of the spine and eyes of a 48 hpf embryo respectively. D and E show the development of the eye, spine, and liver at 72 hpf. F, G, and H show the development of the eye, ear, heart, and spine of the 120 hpf embryo.