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Fig. 5 Actin dynamics in blebs and lamellipodia in NCCs during EMT. Time-lapse sequence of NCCs at the edge of the neuroepithelium in embryos injected with sox10:CAAX-GFP DNA and RFP-UtrCh mRNA. (A) Cell marked with asterisk extends a bleb (arrow). (B) The bleb fills with actin signal upon retraction (arrowhead). (C) The cell blebs again (arrow). (D–F) The cell moves into the bleb while forming actin-filled lamellipodium and filopodia (arrowheads). Images are confocal projections. Dorsal views, anterior left. Scale bar = 10 μm.
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Reprinted from Developmental Biology, 324(2), Berndt, J.D., Clay, M.R., Langenberg, T., and Halloran, M.C., Rho-kinase and myosin II affect dynamic neural crest cell behaviors during epithelial to mesenchymal transition in vivo, 236-244, Copyright (2008) with permission from Elsevier. Full text @ Dev. Biol.