ZFIN Image: Goessling et al., 2008, Fig. S5

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Fig. S5 APC loss affects endodermal fate. (A–C) Insulin and (D–F) trypsin in situ hybridization at 72 hpf in all APC genotypes revealed a decrease in endocrine and exocrine pancreas size in both APC^+/^- (insulin: 51/65; trypsin: 68/74) and APC^-/- (insulin: 25/29; trypsin: 32/32) mutants. The dimensions of the endocrine pancreas in wild-type embryos are indicated with black bars for comparison. An arrowhead highlights a small area of trypsin expression in one homozygous mutant embryo. (G-I) ifabp expression is affected in a similar manner to that seen with lfabp; APC^+/^- embryos had an increase in ifabp (31/55), while there was an absence of expression in homozygous mutants (28/29). The (^) indicates the presence of minimal ifabp expression found in a single embryo.

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Acknowledgments

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Reprinted from Developmental Biology, 320(1), Goessling, W., North, T.E., Lord, A.M., Ceol, C., Lee, S., Weidinger, G., Bourque, C., Strijbosch, R., Haramis, A.P., Puder, M., Clevers, H., Moon, R.T., and Zon, L.I., APC mutant zebrafish uncover a changing temporal requirement for wnt signaling in liver development, 161-174, Copyright (2008) with permission from Elsevier. Full text @ Dev. Biol.