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Fig. S4a Time-dependent modulation of wnt activity affects and liver formation and liver and pancreatic progenitors. (A–J) In situ hybridization for lfabp at 72 hpf. (A–D) wnt8 induction at time points from 26 to 48 hpf increased liver size. (E,F) Activation of dnTCF at the 1 somite (10 hpf) stage led to severe morphological defects (46/51). (G–J) Induction of dnTCF impaired liver growth at all stages examined, with the most significant effects occurring at 10 somites (14 hpf; 122/141).
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Reprinted from Developmental Biology, 320(1), Goessling, W., North, T.E., Lord, A.M., Ceol, C., Lee, S., Weidinger, G., Bourque, C., Strijbosch, R., Haramis, A.P., Puder, M., Clevers, H., Moon, R.T., and Zon, L.I., APC mutant zebrafish uncover a changing temporal requirement for wnt signaling in liver development, 161-174, Copyright (2008) with permission from Elsevier. Full text @ Dev. Biol.