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Figure Caption
Fig. 3 Fine-mapping of the notochord regulatory sequences in ctgf up1. The left panels show gfp expression in the midline of 24 hpf zebrafish embryos. Right panels are schematic representations of the ctgf wild-type promoter (A) and mutant constructs (B to H) cloned upstream of the TATA-box of the ctgf gene and gfp-reporter cassette. Positions give base pairs upstream of the ATG. The transversions introduced to mutate the C1 and C2 elements are indicated. Embryos are anterior left and dorsal up. Scale bar = 250 μm.
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Reprinted from Developmental Biology, 318(2), Rastegar, S., Hess, I., Dickmeis, T., Nicod, J.C., Ertzer, R., Hadzhiev, Y., Thies, W.G., Scherer, G., and Strähle, U., The words of the regulatory code are arranged in a variable manner in highly conserved enhancers, 366-377, Copyright (2008) with permission from Elsevier. Full text @ Dev. Biol.