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Fig. 3 Knock-down of zebrafish itgα7 results in muscle fibre detachments. (A) Phylogenetic tree of the itgα6 and itgα7 sequence of several species. itgα1 of C. elegans and Drosophila was used as an outer group. (B,C) Whole mount ISH with dig-labelled antisense itgα7 mRNA at 15-somite stage (B) and 24 hpf with cross section (C). (D–F) Compared to wt embryos at 4 dpf (D) injections of itgα7-splice MO (E) or itgα7-ATG MO (F) result in muscle fibre detachments.
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Reprinted from Developmental Biology, 318(1), Postel, R., Vakeel, P., Topczewski, J., Knöll, R., and Bakkers, J., Zebrafish integrin-linked kinase is required in skeletal muscles for strengthening the integrin-ECM adhesion complex, 92-101, Copyright (2008) with permission from Elsevier. Full text @ Dev. Biol.