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Figure Caption
Fig. 4 pitx2 expression is disrupted very early in zebrafish one-eyed pinhead (oep) mutant embryos. pitx2 expression in wild-type (A–E) and zygotic oepz1 mutant embryos (F–J). (A–F) 30% epiboly (4.7 h), (B, G) germ ring (5.7 h), (C, H) shield (6 h), (D, I) 75% epiboly (8 h), (E, J) bud (10 h). Note that only a weak pitx2 expression is initiated and that pitx2 transcripts rapidly disappear when the Nodal signaling pathway is inactive.
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Reprinted from Developmental Biology, 229(2), Faucourt, M., Houliston, E., Besnardeau, L., Kimelman, D., and Lepage, T., The pitx2 homeobox protein is required early for endoderm formation and nodal signaling, 287-306, Copyright (2001) with permission from Elsevier. Full text @ Dev. Biol.