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Fig. S1 Effects of Dkk1 overexpression are temporally separable. (A) The mitotic index at 24 hpf is unaffected in all domains of the spinal cord following Dkk1 induction at 18 hpf. Error bars indicate ± S.E.M. (B–C) radar expression is unaffected following late Dkk1 induction. (D–E) Expression of msxc and (F–G) pax3 expression are reduced in dorsal progenitors, and (H–I) expression of dbx2 shifts dorsally when Dkk1 expression is induced at 18 hpf. (B–I) Lateral mounts are shown. Scale bars = 10 μm.
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Reprinted from Developmental Biology, 313(1), Bonner, J., Gribble, S.L., Veien, E.S., Nikolaus, O.B., Weidinger, G., and Dorsky, R.I., Proliferation and patterning are mediated independently in the dorsal spinal cord downstream of canonical Wnt signaling, 398-407, Copyright (2008) with permission from Elsevier. Full text @ Dev. Biol.