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Fig. 5 Transcriptional activation by Lef/Tcf factors mediates progenitor patterning in the spinal cord. (A, B) Expression of msxc and (C, D) pax3 is reduced in ΔTcf-expressing embryos. (E, F) Expression of dbx2 shifts into the dorsal domain of the spinal cord in ΔTcf-expressing embryos, and is ectopically present in the somites. (G, H) Expression of nkx6.2 is unaffected in ΔTcf-expressing embryos. (A–D, G, H) Lateral mounts are shown. (E, F) 12 μm cross-sections are shown. Scale bars = 10 μm.
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Reprinted from Developmental Biology, 313(1), Bonner, J., Gribble, S.L., Veien, E.S., Nikolaus, O.B., Weidinger, G., and Dorsky, R.I., Proliferation and patterning are mediated independently in the dorsal spinal cord downstream of canonical Wnt signaling, 398-407, Copyright (2008) with permission from Elsevier. Full text @ Dev. Biol.