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Fig. 4 COX-1-inhibited embryos are unable to form distinct dorsal aorta and posterior cardinal vein. Cross-section of anterior (A, C) and posterior trunk (E, G) in untreated embryos displays distinct dorsal aorta and posterior cardinal vein. Indomethacin-treated embryos do not form two vascular tubes but display one distended vessel both in anterior (B, D) and posterior sections (F, H). ant, anterior; post, posterior. All embryos were sectioned after staining with flk1.
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Reprinted from Developmental Biology, 282(1), Cha, Y.I., Kim, S.H., Solnica-Krezel, L., and Dubois, R.N., Cyclooxygenase-1 signaling is required for vascular tube formation during development, 274-283, Copyright (2005) with permission from Elsevier. Full text @ Dev. Biol.