ZFIN Image: Nambiar et al., 2007, Fig. 5

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Figure Caption

Fig. 5 tri/vangl2 is able to rescue extension defects and tangential migration of hindbrain branchiomotor neurons in col mutant embryos. Overexpression of tri/vangl2 in col mutants (B and D) is able to rescue the stunted trunk development and broad notochords observed in uninjected col mutants (A and C). Facial (nVII) hindbrain motor neurons labeled by islet1 expression are positioned ectopically in r4 in col mutants at 56 hpf (F) compared to wildtype (E). Overexpression of tri/vangl2 restores tangential migration of these neurons into r6 and r7 (G) as in wildtype siblings (E). nV neurons are positioned correctly in r2 in tri/vangl2 injected (G) and uninjected (F) col mutants.

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Acknowledgments

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Reprinted from Mechanisms of Development, 124(9-10), Nambiar, R.M., Ignatius, M.S., and Henion, P.D., Zebrafish colgate/hdac1 functions in the non-canonical Wnt pathway during axial extension and in Wnt-independent branchiomotor neuron migration, 682-698, Copyright (2007) with permission from Elsevier. Full text @ Mech. Dev.